Evaluation of Bayesian Predictability of Vancomycin Concentration in Patients with Various Degrees of Renal Function.

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Evaluation of Bayesian predictability of vancomycin concentration in patients with various degrees of renal function.

To assess the usefulness of the population pharmacokinetic parameters of vancomycin (VCM) based on a two-compartment model in Japanese adult patients, predictability by a Bayesian method was evaluated using a concentration time course after single dosing to 22 patients with various degrees of renal function. Using one or two points from the observed data for each patient, the concentrations pre...

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ژورنال

عنوان ژورنال: Biological and Pharmaceutical Bulletin

سال: 2001

ISSN: 0918-6158,1347-5215

DOI: 10.1248/bpb.24.1446